The Alvin & Lois Lapidus Cancer Institute Translational Research Laboratory

The Alvin & Lois Lapidus Cancer Institute Translational Research Laboratory is located on the third floor of the Schapiro Building at Sinai Hospital. The aim of translational research is to rapidly move scientific discoveries from the bench to the bedside to ultimately improve patient care. Michael A. Tangrea, Ph.D., leads the research effort with interests in molecular diagnostics, tissue microdissection and genomic medicine.

Expression microdissection (xMD), co-invented by Dr. Tangrea while at the National Cancer Institute, is a tissue microdissection technology that isolates cellular and subcellular targets from a heterogeneous tissue specimen. The ability to rapidly and specifically procure cells of interest allows for precise downstream molecular analysis (DNA, RNA and protein). This new technology may enhance molecular diagnostics in the clinic. Working with clinicians and residents, the Translational Research Laboratory is engaged in research studies of triple negative breast cancer, lung cancer, chronic lymphocytic leukemia and melanoma.

The Translational Research Laboratory also trains undergraduate students. Currently, the laboratory has students from Loyola University Maryland, Towson University and Stevenson University.

Dr. Tangrea would like to thank the Kahlert Foundation, Mr. Curtis Fichter and the Eddie Dopkin Family for their generous support of these research efforts.

Please contact Dr. Tangrea if you are interested in learning more about the Translational Research Laboratory.

Michael A. Tangrea, Ph.D.
Director, Translational Research
Alvin & Lois Lapidus Cancer Institute
Sinai Hospital
2401 W. Belvedere Ave.
Baltimore, MD 21215
410-601-5643
mtangrea@lifebridgehealth.org