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Clinical Research

August 2003

Colon/Colorectal Cancer

  • SWOG N9841: A Randomized Phase III Equivalence Trial of Irinotecan (CPT-11) Versus Oxaliplatin (OXAL)/5-Fluorouracil (5-FU)/Leucovorin (CF) in Patients With Advanced Colorectal Carcinoma Previously Treated With 5-FU
  • SWOG R9811: A Phase III Randomized Study Of 5-Fluorouracil, Cisplatin, and Radiotherapy Vs. 5 Fluorouracil, Mitomycin-C and Radiotherapy in Carcinoma of the Anal Canal

Melanoma

  • SMT 9801: A Multicenter Trial of Adjuvant Interferon Alfa-2b for Melanoma Patients With Early Lymph Node Metastasis Detected by Lymphatic Mapping and Sentinel Lymph Node Biopsy
  • ACOSOG Z0020: Randomized Phase III Trial of Hyperthermic Isolated Limb Perfusion and Melphalan with or without Tumor Necrosis Factor in the Patient with Localized, Advanced, Extremity Melanoma
  • SWOG E4697: A Randomized, Placebo-Controlled Phase III Trial of Yeast Derived GM-CSF Versus Peptide Vaccination Versus GM-CSF Plus Peptide Vaccination Versus Placebo in Patients with “No Evidence of Disease” after Complete Surgical Resection of “Locally Advanced” and/or Stage
    IV Melanoma
  • SWOG 0008: Phase III Trial of High Dose Interferon Alpha-2b Versus Cisplatin, Vinblastine, DTIC Plus IL-2 and Interferon in Patients with High Risk Melanoma.
  • SWOG E1697: Phase III Randomized Study of Four Weeks High Dose IFN-2b in Stage T3-T4 or N1 (microscopic)Melanoma

Breast Cancer

  • SWOG N9831: Phase III Trial of Doxorubicin and Cyclophosphamide (AC) Followed by Weekly Paclitaxel With or Without Trastuzumab as Adjuvant Therapy for Women with HER-2 Overexpressing Node Positive Breast Cancer
  • ACOSOG Z0011: A Randomized Trial of Axillary Node Dissection in Women with Clinical T1-2 N0 M0 Breast Cancer Who Have a Positive Sentinel Node
  • CTSU NSABP-33: A Randomized, Placebo-Controlled, Double-Blind Trial Evaluating the Effect of Exemestane in Clinical Stage T1-3 N0-1 M0 Postmenopausal Breast Cancer Patients Completing at Least Five Years of Tamoxifen Therapy
  • NSABP B-34: A Clinical Trial Comparing Adjuvant Clodronate Therapy Versus Placebo in Early Stage Breast Cancer Patients Receiving Systemic Chemotherapy And/Or Tamoxifen or No Therapy

Gastro-intestinal Cancer

  • ACOSOG Z9000: A Phase II Study of Adjuvant STI571 (GleevecTM) Therapy in Patients Following Completely Resected High-risk Primary Gastrointestinal Stromal Tumor (GIST)
  • ACOSOG Z9001: A Phase III Randomized Double-blind Study of Adjuvant STI571 (GleevecTM) Versus Placebo in Patients Following The Resection of Primary Gastrointestinal Stromal Tumor (GIST)

Lung Cancer

  • S9900: A Randomized Phase III Trial of Surgery Alone or Surgery Plus Preoperative Paclitaxel/Carboplatin in Clinical Stage IB (T2 N0), II (T1-2 N1, T3 N0) and Selected III A (T3 N1) Non-Small Cell Lung Cancer (NSCLC)
  • S9925: Lung Cancer Specimen Repository Protocol, Ancillary
  • EPP 9633: A Phase III Study of Adjuvant Chemotherapy After Resection for Patients with T2 N0 Stage I Non-Small Cell Carcinoma of the Lung
  • S0023: A Phase III Trial of Cisplatin /Etoposide/Radiotherapy With Consolidation Docetaxel Followed by Maintenance Therapy with ZD1839 or Placebo in Patients With Inoperable Locally Advanced Stage III Non-Small Cell Lung Cancer
  • D0112: A Multi-Center, Randomized Phase III Study of Taxotere and Carboplatin versus Taxotere and Gemcitabine in Patients with Advanced Non-Small Cell Lung Cancer
  • Amgen 20020121: A Pilot Study of the Effects of Neutropenia on Patient Reported Outcomes during Chemotherapy with or without NeulastaTM (pegfilgrastim) in Subjects with Advanced NSCLC

Prostate Cancer

  • RTOG P-0019: A Phase II Study of External Beam Radiation Therapy Combined with Permanent Source Brachytherapy for Intermediate Risk Clinically Localized Adenocarcinoma of the Prostate

Endometrial Cancer

  • RTOG 99-05: A Phase III Study of Adjuvant Postoperative Irradiation With or Without Cisplatin/Taxol Chemotherapy Following TAH/BSO for Patients with Endometrial Cancer

MDS

  • SWOG-9007: Cytogenetic Studies in Leukemia Patients
  • SWOG 9910: Leukemia Centralized Reference Laboratories and Tissue Repositories, Ancillary

Leukemia

  • E2997: Phase III Randomized Trial of Fludarabine and Cyclophosphamide versus Fludarabine for Previously Untreated Chronic Lymphocytic Leukemia
  • Amgen 20020163: A Multicenter, Double-Blind, Randomized Phase II Trial Comparing Pegfilgrastim with Filgrastim as an Adjunct to Chemotherapy for Acute Myeloid Leukemia

Liver Cancer

  • ZX101-301: A Phase III Randomized Controlled Study Comparing the Survival Of Patients With Unresectable Hepatocellular Carcinoma (HCC) Treated With THYMITAQTM to Patients Treated With Doxorubicin

Bone Metastases

  • ACRIN 6661: A Phase I/II Study of Percutaneous Radiofrequency Ablation of Bone Metastases Using CT Guidance

Lymphoma

  • SWOG 9438: Total Body Irradiation, Etoposide, Cyclophosphamide and Autologous Peripheral Blood Stem Cell Transplantation Followed by Randomization to Therapy With interleukin-2 Versus Observation for Patients With Non-Hodgkin’s Lymphoma, a BMT Study, Phase III
  • Amgen 20020134: A Multicenter, Double-Blind, Randomized Phase II Study of Pegfilgrastim Administered on the Same Day or the Next Day of R-CHOP Chemotherapy in Subjects with Non-Hodgkin's Lymphoma

Supportive Care

  • Amgen 20020122: A Randomized, Open Label, Multicenter Study of Primary Prophylaxis with NeulastaTM (pegfilgrastim) Versus Secondary Prophylaxis as an Adjunct to Chemotherapy in Elderly Subjects (³ 65 y.o.) with Cancer
  • ARK 201: A Phase III, Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel Group, Dose-Titration Study of Imidapril Hydrochloride (EG006) in the Treatment of Cancer Cachexia
  • PRO2-27-047: A Randomized, Open-Label Study of Epoetin Alfa (PROCRIT®) Versus Darbepoetin Alfa (ARANESPTM) To Evaluate Hematologic Response Rate in Anemic Cancer Patients Receiving Chemotherapy

    Oncology Research Team:

    Judy Bosley, RN Clinical Research Nurse
    Lynn Crawford, RN Clinical research Nurse
    Yana Rachinskaya, MS Clinical Research Program Coordinator

    The Alvin & Lois Lapidus Cancer Institute
    2401 West Belvedere Avenue
    Baltimore, Maryland 21215
    Phone: 410-601-6120
    Fax: 410-601-4714

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